A simple, accurate, precise and sensitive reverse phase high performance liquid chromatographic method was developed for simultaneous estimation of candesartan cilexetil and pioglitazone hydrochloride in synthetic mixture. C18, 250 mm X 4.6 mm, 5 μm particle size in isocratic mode with mobile phase acetonitrile: methanol: water (70:10:20 v/v/v) and pH adjusted to 5.0±0.1 with ortho phosphoric acid was used. The flow rate was 1.0 ml/min and absorbance of individual component was measured at 269 nm. The retention times of candesartan cilexetil and pioglitazone hydrochloride were found to be 8.11 and 4.23 min, respectively. Linearity for candesartan cilexetil and pioglitazone hydrochloride was in the range of 10-250 and 20-500 μg/ml with correlation coefficient values 0.9996 and 0.9997 the percentage recovery obtained was 99.50-99.73 % and 99.54-99.98 %, respectively.
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